Brain derived biomarkers for the assessment of Alzheimer’s disease (AD) or other neurodegenerative diseases (ND) can be detected in cerebrospinal fluid (CSF) and along the brain nose interface (BNI). The BNI (fig. 1) constitutes an important, direct drainage route for CSF and its metabolites along the olfactory route into the nose. The analysis of nasal CSF (nCSF) enables a non-invasive detection and stratification of core AD and ND biomarkers. The status of oligomerization as well as the quantification of core biomarkers can be assessed non-invasively using our proprietary method.

To date, only limited knowledge exists for the collection of nCSF from the vicinity of the BNI, the pre-analytical processing and subsequent in vitro analysis of the core AD associated biomarkers.

We developed a proprietary diagnostic platform leveraging nCSF. Our analysis allows a detailed quantification of the following core AD biomarkers regarding their relative protein amount and their grade of oligomerization:

  • Amyloid-ß1-42 (Aß42)
  • Amyloid-ß1-40 (Aß40)
  • (Total) Amyloid-ß (Aß)
  • pTau181 (pTau)
  • total Tau (tTau)


Noselab’s proprietary diagnostic platform enables

  • a standardized collection of nCSF from the vicinity of the BNI
  • a standardized analysis of the collected nCSF
  • a detailed quantification and assessment of relative protein amount and protein specific oligomerization state in nCSF.

Aim of this study was to compare core AD biomarker-patterns of nCSF to CSF (collected via lumbar puncture) in patients with cognitive impairment, to evaluate the different monomeric and oligomeric structures of each core protein and to evaluate the diagnostic utility of our proprietary diagnostic platform.

Fig. 1 Brain nose interface (BNI)
The BNI constitutes a drainage route for nCSF and its biomarkers.

This publication was initially presented at the 16th iteration of the Clinical Trials in Alzheimer’s Disease (CTAD) conference, held October 24-27, 2023, in Boston.

We’re excited to meet you at the upcoming AD/PD™ 2024, March 5-9, 2024, in Lisbon. Learn more about our participation and the latest publications here.

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